*********************************************************
The Public Health Laboratory Services Branch (PHLSB) of the Centre for Health Protection (CHP) of the Department of Health confirmed today (April 15) a case of New Delhi metallo-β-lactamase-1 (NDM-1) Carbapenemase-producing Enterobacteriaceae in a 5-year-old boy.
The boy, with good past health, travelled to Pakistan from March 15 to April 5 and was admitted to a hospital there for fever and vomiting on March 28. He was diagnosed as acute renal failure and managed with haemodialysis and blood transfusion. He returned to Hong Kong and was admitted to Princess Margaret Hospital on April 5 for further management. His current condition is stable.
The patient's blood grew NDM-1 Carbapenemase-producing Enterobacteriaceae as confirmed by the PHLSB.
His family contacts are asymptomatic. Investigations by the CHP are underway.
This is the 26th detected case of NDM Carbapenemase-producing Enterobacteriaceae in Hong Kong.
NDM is an enzyme which can inactivate carbapenems and other beta-lactams such as penicillins. Bacteria harbouring this NDM gene are commonly resistant to multiple antimicrobials, limiting therapeutic options and rendering severe clinical infections difficult to treat. Most bacteria with the NDM enzyme remain susceptible to two types of antibiotics, colistin and tigecycline.
Infections have varied from being asymptomatic to potentially life-threatening or fatal. The level of risk depends on which part of the body is affected by the infection, and the general health of the patient.
NDM-producing Enterobacteriaceae was first reported in a Swedish patient of Indian origin who travelled to New Delhi, India, in 2008. The first fatal case was identified in 2010 in a patient who received medical treatment in Pakistan before being repatriated to Belgium.
NDM-producing Enterobacteriaceae has now been reported in many countries and regions including Australia, Austria, Canada, Belgium, France, Germany, Japan, the Netherlands, Norway, Oman, Sweden, Singapore, Taiwan, the UK and the US. Most patients had prior hospital contact in the Indian subcontinent.
A CHP spokesman said that proper use of antibiotics and personal hygiene, especially hand hygiene, are important for the prevention of emergence and cross-transmission of NDM strains.
Ends/Monday, April 15, 2013
Issued at HKT 19:53
NNNN
